Contents Chapter 1 General introduction and outline of the thesis 9 Chapter 2 Preliminary results of a cohort study of induction chemotherapy-based treatment for locally recurrent rectal cancer 19 DMGI vanZoggel, SJBosman,MKusters,GAPNieuwenhuijzen, JS Cnossen, GJ Creemers, G van Lijnschoten, HJT Rutten Br J Surg. 2018 Mar;105(4):447-452 Chapter 3 Improved outcomes for responders after treatment with induction chemotherapy and chemo(re)irradiation for locally recurrent rectal cancer 33 ELKVoogt, DMGI vanZoggel,MKusters, GAPNieuwenhuijzen, JG Bloemen, HMU Peulen, GJ Creemers, G van Lijnschoten, J Nederend, MJ Roef, JWA Burger, HJT Rutten Ann Surg Oncol. 2020 Sep;27(9):3503-3513 Chapter 4 Local recurrence in the lateral lymph node compartment: improved outcomes with induction chemotherapy combined with multimodality treatment 55 MKusters, SJBosman,DMGI vanZoggel,GAPNieuwenhuijzen, GJ Creemers, HA vd Berg, HJT Rutten Ann Surg Oncol. 2016 Jun;23(6):1883-9 Chapter 5 Impact of a history of metastases or synchronous metastases on survival in patients with locally recurrent rectal cancer 71 DMGI vanZoggel, ELKVoogt,MKusters, GAPNieuwenhuijzen, JS Cnossen, GJ Creemers, G van Lijnschoten, J Nederend, MJ Roef, JWA Burger, HJT Rutten Colorectal Dis. 2021 May;23(5):1120-1131 Chapter 6 MRI tumour regression grade in locally recurrent rectal cancer 99 ELK Voogt, S Noordkamp, DMGI van Zoggel, AW DaniëlsGooszen, GAP Nieuwenhuijzen, JG Bloemen, GJ Creemers, JS Cnossen, G van Lijnschoten, JWA Burger, HJT Rutten, J Nederend BJS Open. 2022 May;6(3):zrac033
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