Impact of metastases on survival 85 CHAPTER 5 In LRFS, positive lymph nodes with the primary resection (HR 1.43; 95 percent CI 1.01– 2.01; P = 0.044) and an R1/2 resection (HR 3.98; 95 percent CI 2.83–5.59; P < 0.001) were associatedwith aworseLRFS, whereas neoadjuvant treatmentwith full- course (chemo) radiotherapy (HR 0.34; 95 percent CI 0.16-0.88; P = 0.014) and (chemo)reirradiation (HR 0.52; 95 percent CI 0.29–0.91; P = 0.024) were associated with an improved LRFS. The MFS was negatively associated with a positive lymph node stage of the primary tumour (HR 1.76; 95 percent CI 1.27–2.45; P = 0.001) and an R1/2 resection (HR 2.25; 95 percent CI 1.64–3.09; P < 0.001), whereas neoadjuvant treatment with (chemo) reirradiation positively influenced theMFS (HR 0.50; 95 percent CI 0.29–0.86; P =0.013). Moreover, patients with synchronousmetastases had aworseMFS (HR 3.25; 95 percent CI 2.11–5.02; P < 0.001).
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