Impact of metastases on survival 87 CHAPTER 5 Overall survival (Continued) Local recurrence-free survival P-value HR CI P-value HR CI P-value HR CI P-value 1.00 - 1.00 - 0.008 1.62 1.23-2.14 0.001 0.81 0.59-1.12 0.202 1.00 - 0.681 1.24 0.88-1.73 0.214 1.00 - 0.685 1.24 0.88-1.73 0.155 1.00 - 1.00 - 0.042 1.36 0.92-2.01 0.119 1.18 0.79-1.76 0.413 1.00 - 1.00 - 1.00 - 0.001 1.38 1.02-1.89 0.040 1.70 1.22-2.36 0.002 1.43 1.01-2.01 0.044 1.00 - 1.00 - 1.00 - 0.113 0.96 0.53-1.72 0.879 1.90 1.28-2.83 0.001 1.01 0.51-2.00 0.973 0.033 1.03 0.57-1.86 0.933 2.44 1.65-3.61 <0.001 1.12 0.57-2.19 0.750 1.00 - 0.875 0.90 0.39-2.04 0.791 0.660 1.15 0.49-2.68 0.751 1.00 - 0.870 1.19 0.80-1.76 0.396 1.00 - 0.954 1.22 0.80-1.88 0.356 1.00 - 1.00 - 0.960 1.59 1.15-2.19 0.005 1.41 0.99-2.02 0.055 1.00 - 1.00 - 1.00 - 0.920 0.79 0.17-3.74 0.764 0.87 0.20-3.82 0.856 1.09 0.22-5.49 0.915 0.003 0.42 0.21-0.81 0.010 0.25 0.13-0.46 <0.001 0.34 0.16-0.88 0.014 0.058 0.50 0.30-0.84 0.009 0.59 0.34-1.02 0.058 0.52 0.29-0.91 0.024 1.00 - 1.00 - 1.00 - 0.920 0.79 0.17-3.74 0.764 0.87 0.20-3.82 0.856 1.09 0.22-5.49 0.915 0.003 0.42 0.21-0.81 0.010 0.25 0.13-0.46 <0.001 0.34 0.16-0.88 0.014 0.058 0.50 0.30-0.84 0.009 0.59 0.34-1.02 0.058 0.52 0.29-0.91 0.024 1.00 - 0.299 1.17 0.75-1.83 0.477 1.00 - 1.00 - 0.579 0.76 0.48-1.20 0.240 1.44 0.91-2.27 0.119 0.066 1.25 0.83-1.87 0.288 1.22 0.73-2.03 0.450 1.00 - 0.542 0.88 0.47-1.67 0.700 1.00 - 1.00 - 1.00 - <0.001 2.06 1.55-2.74 <0.001 3.92 2.85-5.41 <0.001 3.98 2.83-5.59 <0.001
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