Femke Mathot

7 Motor results of MSC-seeded nerve allografts 117 Isometric Tetanic Force (ITF) (figure 4) The ITF ratio of allografts seeded with undifferentiated MSCs (49.74 ± 6.80%) was significantly higher compared to unseeded allografts (26.32 ± 4.36%) (p=0.017) at 12 weeks. The ratio in autografts (44.16 ± 3.32%) and allografts seeded with differentiated MSCs (43.10 ± 4.59%) did not demonstrate significant differences with any of the other groups. At 16 weeks, the ITF ratio of autografts (51.11 ± 4.98%), allografts (56.22 ± 4.44%), allografts with undifferentiated MSCs (56.12 ± 6.51%) and allografts with differentiated MSCs (53.86 ± 4.47%) did not significantly differ. Figure 3. Compound muscle action potential ratios (CMAP, R/L) at 12 and 16 weeks. CMAP recovery of unseeded allografts was significantly inferior compared to all other groups at 12 weeks uMSCs = undifferentiated Mesenchymal Stem Cells; dMSCs = differentiated Mesenchymal Stem Cells * = p<0.05, ** = p<0.01, *** = p<0.001. Error bars = Standard error of the mean Figure 4. Isometric Tetanic Force ratios (R/L) at 12 and 16 weeks. ITF recovery of unseeded allografts were significantly inferior compared to allografts seeded with undifferentiated MSCs at 12 weeks uMSCs = undifferentiated Mesenchymal Stem Cells; dMSCs = differentiated Mesenchymal Stem Cells * = p<0.05, ** = p<0.01, *** = p<0.001. Error bars = Standard error of the mean