Femke Mathot

Chapter 9 154 in MSCs seeded onto Avance® Nerve Grafts (1.326 ± 0.097, p=0.030). The expression curve of the NeuraGen® Nerve Guide group seemed to increase on the long term, while the expression curve of the Avance® Nerve Graft group remained stable on the long term. The obtained CD96 expressions demonstrated a slight upregulation in comparison to baseline gene expression of unseeded MSCs at most time points. Figure 3. Gene expression curves of MSCs seeded onto Avance® Nerve Grafts and NeuraGen® Nerve Guides concerning angiogenic genes VEGF-a and CD31 at 6 different time points after seeding. * = p<0.05, Error bars = Standard error of the mean Figure 4. Gene expression curves of MSCs seeded onto Avance® Nerve Grafts and NeuraGen® Nerve Guides concerning extracellular matrix genes COL1A1, COL3A1, FBLN1 and LAMB2 at 6 different time points after seeding. ** = p<0.01, *** = p<0.001, Error bars = Standard error of the mean