Femke Mathot

TABLE OF CONTENTS Chapter 1 General introduction and outline of this thesis 11 Chapter 2 Targeted stimulation of mesenchymal stem cells in peripheral 27 nerve repair Gene. 2019 August;710:17-23 Chapter 3 Adhesion, distribution and migration of differentiated and 43 undifferentiated mesenchymal stem cells (MSCs) seeded on nerve allografts Journal of plastic, reconstructive & aesthetic surgery: JPRAS. 2020 January;73(1):81-89 Chapter 4 Gene expression profiles of differentiated and undifferentiated 59 adipose derived mesenchymal stem cells dynamically seeded onto a processed nerve allograft Gene. 2020 January; 724:144151 Chapter 5 New methods for objective angiogenesis evaluation of rat 79 nerves using microcomputed tomography scanning and conventional photography Microsurgery. 2020 March;40(3):370-376 Chapter 6 Adipose derived Mesenchymal Stem Cells seeded onto a 93 decellularized nerve allograft enhances angiogenesis in a rat sciatic nerve defect model Microsurgery. 2020 July;40(5):585-592 Chapter 7 Functional outcomes of nerve allografts seeded with 109 undifferentiated and differentiated mesenchymal stem cells in a rat sciatic nerve defect model Plastic and Reconstructive Surgery. 2021 June. Online ahead of print. Chapter 8 Introducing human adipose derived mesenchymal stem cells 127 to Avance® nerve grafts and NeuraGen® nerve guides Journal of plastic, reconstructive & aesthetic surgery: JPRAS. 2020 April;73(8)1473-1481 Chapter 9 Gene expression profiles of human adipose-derived mesenchymal 143 stem cells dynamically seeded on clinically available processed nerve allografts and collagen nerve guides Neural Regeneration Research. 2021 August;16(8):1613-1621 Chapter 10 General discussion and future perspectives 167 Chapter 11 Summary & Dutch summary 185 Appendices Research data management 197 List of publications 199 PhD Portfolio 201 Curriculum Vitae 203 Dankwoord 205