Tiam Mana Saffari

114 CHAPTER 6 analyzed using an unpaired student t-test. Results were reported as the mean and standard error of the mean (SEM), and the level of significance was set at α ≤ 0.05. Table 2. Investigated genes including their description and function. Gene Symbol Description Function Gapdh Glyceraldehyde-3-phosphate dehydrogenase Housekeeping gene Actb Cytoskeletal protein β-actin Housekeeping gene Neurotrophic markers Gdnf Glial cell derived neurotrophic factor Promotes survival of neurons by prevention of apoptosis Ngf Nerve growth factor Guider of axonal growth and promotes Schwann cell activity Pmp22 Peripheral myelin protein 22 Schwann cell growth, important component of myelin Ptn Pleiotrophin Neuronal protection Angiogenic markers Vegfa Vascular endothelial growth factor a Proliferation and migration of vascular endothelial cells Pecam1/Cd31 Platelet endothelial cell adhesion molecule or Cd31 Maintains vascular permeability barrier Mmp2 Matrix metallopeptidase 2 Expression is correlated with increased angiogenesis Cd34 Cd34 molecule Role in early hematopoiesis Immunogenic markers Cd4 Cd4 molecule Helper T cells Cd8 Cd8 molecule Cytotoxic T cells Tnf Tumor necrosis factor Inflammation – type M1 macrophages Extracellular matrix (ECM) markers Col1A1 Type I collagen Interaction with ECM Col3A1 Type III collagen Interaction with ECM Fbln1 Fibulin1 Perineurium of peripheral nerve Lamb2 Laminin subunit beta 2 Regulates cell growth, motility and cell adhesion