Tiam Mana Saffari

246 CHAPTER 11 Figure 2. Schematic drawing of interaction between stem cells, vascularity, and nerve regen - eration. After a nerve injury, paracrine cues are provided to stem cells to produce trophic and angiogenic factors that enhance nerve regeneration and angiogenesis, respectively. Blood supply mobilizes stem cells and delivers nutrients and trophic factors to the site of injury to improve nerve regeneration. Blood supply is not only important for the survivability of stem cells but also precedes nerve regeneration after nerve trauma. Copyrighted and used with permission of the Mayo Founda- tion for Medical Education and Research; all rights reserved.