Marieke van Son

127 TOXICITY AFTER ULTRAFOCAL SALVAGE HDR-BRACHYTHERAPY continence: one had overflow incontinence due to bladder neck stenosis and one had severe stress incontinence. Highest recorded new-onset GI toxicity was grade 1 in 47/150 patients (31%), which was mainly mild flatulence, rectal discomfort or mild rectal hemorrhage. Maximum grade 2 GI toxicity occurred in 8/150 patients (5%), mainly in the form of rectal hemor- rhage needing minor cauterization (4/8). No grade 3 GI toxicity was seen. In 7/150 (5%) patients, highest recorded new ED was grade 1. Maximum grade 2 ED was seen in 33/150 patients (22%) and maximum grade 3 ED in 22/150 (15%) patients. Toxicity per time point A subdivision of new-onset toxicity per follow-up time point is graphically displayed in Figures 1a–c. At each time point, the bars represent toxicity as compared to base- line. New grade 1 GU toxicity was mostly recorded in the first month, while grade 2 and 3 GU toxicity peaked between six and twelve months. GI toxicity generally de- creased over time. The occurrence of grade 2-3 ED was relatively stable. For more detail, supplementary Figures 1 a–f and 2 a–j (available online at https://doi.org/10.1016/j. ctro.2020.12.002) display new-onset toxicity per GU/GI subdomain. Figure 1‑a 7