Marieke van Son

33 RADICAL VS. FOCAL TREATMENT FOR LOCALIZED PROSTATE CANCER A B Figure 1 – two-way survival analysis, displaying propensity weighted failure-free survival and overall survival against time for patients treated with radical (EBRT or LRP) and focal therapy. A B Figure 2 – three-way survival analysis, displaying propensity weighted failure-free survival and overall survival against time for patients treated with EBRT, LRP and focal therapy. Three-way analysis Results from the three-way PSW-analysis (EBRT versus LRP versus FT) are displayed in Supplementary Table 1 (covariate balance assessment) and Supplementary Table 2 (Cox regression estimates). Balance was achieved for most covariates except for age (mean 66.2 versus 65.3 versus 66.6, SMD 0.161). Both FT and LRP patients had a higher risk of treatment failure than the EBRT group (both p <0.001), but there was no statistically significant difference between FT and LRP ( p =0.69). In terms of overall mortality, the only significant difference was between focal and EBRT patients, with a lower risk of death after FT (HR 0.29, 95% CI 0.11-0.76; p =0.008). 2