Marieke van Son

50 CHAPTER 3 Table 2 – Toxicity Baseline N=30 1 mo N=30 3 mo N=28 6 mo N=27 9 mo N=24 12 mo N=29 18 mo N=28 24 mo N=25 36 mo N=26 48 mo N=17 GU Grade 1 Grade 2 Grade 3 14 0 0 12 1 0 7 1 0 6 0 0 6 0 0 8 0 0 5 1 0 3 2 0 7 1 0 3 1 0 GI Grade 1 Grade 2 Grade 3 15 2 0 18 2 0 13 0 0 11 0 0 12 0 0 12 0 0 11 0 0 4 0 0 1 0 0 1 0 0 ED Grade 1 Grade 2 Grade 3 7 3 5 8 6 5 7 6 5 7 7 7 3 5 8 7 11 4 3 8 7 7 5 5 9 6 6 3 8 1 Abbreviations: GU=genitourinary; GI-gastro-intestinal; ED=erectile dysfunction, mo=months IPSS showed the largest increase in the first month, from median score 5 (IQR 4-7) to 8 (6-13), corresponding to progression from mild symptoms to moderate symptoms.. Median IIEF score decreased from 19 (5-22) at baseline to 6 at 6 months, (significant at the 0.001 level), and remained at a lower level until 48 months follow-up. This cor- responds to a clinical decrease from mild to moderate/severe ED. IPSS and IIEF are depicted in figure 2. Figure 2 – International Prostate Symptom Score (A) and International Index of Erectile Function (B) scores. Medians with interquartile ranges are depicted.