Marieke van Son

67 FOCAL SALVAGE TREATMENT: A NARRATIVE REVIEW Figure 1 – Recurrent prostate cancer lesion on diagnostic 3T multiparametric-magnetic reso- nance imaging (mp-MRI) (a,b,c) and PSMA-PET/CT (d). The suspect lesion is visible in the right peripheral zone of the apex. Delineations of the prostate (green), gross tumor volume (GTV, red) and clinical target volume (CTV, blue) are displayed. (a) T2-weightedMRI, (b) ADCmap of DWI-MRI, (c) K-trans map of DCE-MRI, (d) 68Ga-PSMA-PET/CT Biopsies In the primary setting it was shown that MRI-targeted biopsies, as opposed to tran- srectal ultrasonography (TRUS)-guided biopsies, decrease the detection of insignificant disease, while the yield of clinically relevant cancers increases [63]. A study in which patients subsequently underwent mp-MRI, TRUS-biopsies and transperineal template prostate mapping (TPM) biopsies (sampling the whole gland every 5 mm), calculated that up to 18% more cases of clinically significant cancer might be detected if TRUS-bi- 4