Dolph Houben

6 TABLE OF CONTENTS PART 1 Chapter 1 Introduction and Outline of the Thesis 11 Chapter 2 Vascularized bone grafts, a closer look at the free fibula flap for lower extremity reconstruction 31 Chapter 3 Combined massive allograft and intramedullary vascularized fibula as the primary reconstruction method for segmental bone loss in the lower extremity: a systematic review and meta-analysis 55 PART 2 Chapter 4 Outcomes of vascularized bone allotransplantation with surgical induced autogenous angiogenesis in a large animal model: bone healing, remodeling and material properties 75 Chapter 5 Neo-angiogenesis, transplant viability and molecular analyses of vascularized bone allotransplantation surgery in a large animal model 95 Chapter 6 Transplant chimerism in porcine structural vascularized allotransplants 115 Chapter 7 Autogenous arteriovenous bundle implantation maintains viability without increased immune response in large porcine bone allotransplants 134