Josephine van Dongen

Chapter 5 134 Characteristic NIP vaccinated (N=5) NIP + HRV vaccinated (N=22) Parental education # High Medium Lower 3 (60.0) 2 (40.0) 0 15 (62.8) 6 (27.3) 1 (4.5) Parental background ^ European Non-European Mixed 3 (60.0) 2 (40.0) 14 (63.6) 4 (18.2) 4 (18.2) Average parental age in years (median, IQR) 30.5 (17.7-43.3) 34.5 (27.5-41.5) Parent reported solicited adverse event Any solicited adverse event 4 (80%) 15 (68%) Fever 3 (60%) 8 (36%) Gastrointestinal adverse event 2 (40%) 4 (18%) Any AE related healthcare attendance 3 (60%) 8 (36%) For the subgroup of infants with GA before 27 weeks, we only took those receiving care in a hospital with a policy to vaccinate off-label, as our study population. Percentages are derived excluding subjects with missing data on the variable. £ Based on 10th percentile perinatal growth curves. # Based on highest parental educational level. ^ Based on parental background and categorized according to world population by country. Abbreviations: N = number in group, SD = standard deviation, IQR = interquar tile range, NIP = national immunization program, HRV = human rotavirus vaccine. Table S4 . Solicited AE following receipt of NIP vaccines or concomitant NIP+HRV vaccination as par t of the primary series in off-label subgroup of high-risk premature infants (gestational age < 27 weeks) Repor ted adverse events after primary series vaccine administrations Any NIP vaccination (N=14) Concomitant NIP+HRV vaccination (N=17) At least one solicited adverse event 9 (64.3%) 7 (41.2%) Fever 4 (28.6%) 4 (23.5%) Gastrointestinal adverse event 2 (14.3%) 2 (11.8%) Any healthcare attended 3 (21.4%) 3 (17.6%) Hospitalization 3 (21.4%) 2 (11.8%) For the subgroup of infants with GA before 27 weeks, we only took those receiving care in a hospital with a policy to vaccinate off-label, as our study population. #1 missing information on solicited adverse events.Abbreviation: NIP = national immunization program, HRV = human rotavirus vaccine, N = number in group