Josephine van Dongen

6 Non-specific effects of human rotavirus vaccination 147 Table 1 Baseline table with characteristics of vaccinated and unvaccinated infants According to protocol groups protocol (ATP) Pre-implementation: willing to vaccinate N=496 Post-implementation: vaccinated N=719 p-value Male sex 286 (57.7%) 381 (53.0%) 0.11 Multiple births 115 (23.8%) 193 (26.8%) 0.15 Premature birth (gestation < 37 weeks) 432 (87.8%) 635 (88.3%) 0.79 Small for gestational age £ 135 (27.2%) 238 (33.1%) 0.03 Presence of severe congenital disorder * 95 (19.2%) 106 (14.7%) 0.04 Vaccinated according to NIP 484 (97.6%) 652 (90.7%) <0.001 Daycare attendance 289 (58.6%) 398 (59.6%) 0.74 Socioeconomic status ^ Higher Moderate Lower 352 (71.5%) 119 (24.2%) 21 (4.3%) 492 (74.1%) 153 (23.0%) 19 (2.9%) 0.36 Parental origin # European parent(s) Non-European parent(s) Mixed 417 (84.8%) 28 (5.7%) 47 (9.6%) 557 (83.4%) 38 (5.7%) 73 (10.9%) 0.75 Mean number of months with completed follow-up (SD) 16.4 (5.5) 14.9 (6.5) <0.001 Number with complete follow-up until 18 months of age 380 (76.6%) 450 (62.6%) <0.001 Mean proportion of months during ARI season (SD) $ 0.50 (0.18) 0.50 (0.18) 0.75 Percentages are computed excluding subjects with missing data on the variable. Statistical significance (p-value <0.05) is highlighted in bold. £ Based on the 10th percentile perinatal growth curves. * For a list of qualifying congenital disorders, see chapter 4. ^ Based on highest parental education level. # Based on parental origin byWorld population by country .25 $ ARI season in the Netherlands is defined from October until April. 26 Abbreviations: GA= gestational age, SD= standard deviation, IQR = interquar tile range, yrs= years, NIP = National Immunization Program and, N = number in group.