Josephine van Dongen

6 Non-specific effects of human rotavirus vaccination 149 Based on the adjusted Cox model at least one dose of HRV was not significantly protective against first acute hospitalization (HR for time to first acute hospitalization 0.91; 95%CI 0.71;1.18, table 3 ). The final model included gestational age, presence of a congenital disorder, type of hospital care and seasonality as covariates. In addition, no effect was observed on the occurrence of ARI (adjusted incidence rate ratio (IRR) 1.05; 95%CI 0.96;1.15), or eczema (adjusted IRR: 0.89; 95%CI 0.69;1.15, table 3 ). Comparing the secondary outcomes of cumulative or hospitalization days showed no statistically significant difference.The cumulative number of days with ARI was increased for vaccinated infants ( table 3 ). Table 3 Effect estimates of non-specific effects Univariate 95% CI Multivariate estimate Lower 95% CI Upper 95% CI HR for acute hosp- italization * 0.85 0.66-1.09 0.91 0.71 1.18 IRR for ARI # 1.07 0.99-1.17 1.05 0.96 1.15 IRR for eczema # 0.94 0.74-1.18 0.89 0.69 1.15 Secondary RR Cumulative number of days hospitalized 0.91 0.66-1.25 0.83 0.59 1.16 RR Cumulative number of days with ARI 1.06 1.04-1.09 1.06 1.03 1.09 Sensitivity HR for infectious diseases hosp- italization * 0.93 0.56-1.60 0.96 0.58 1.62 HR for acute hospitalization until 6 months * 1.08 0.76-1.53 1.20 0.85 1.71 HR for acute hospitalization until 11 months * 0.87 0.65-1.16 0.95 0.71 1.27 IRR for ARI until 6 months # 1.05 0.89-1.24 0.94 0.78 1.14