Josephine van Dongen

Chapter 6 152 between vaccinated and unvaccinated infants. Duration of disease could function as a proxy for severity. In conclusion, rotavirus vaccination in medical risk infants was not associated with beneficial non-specific effects on (acute hospitalization due to) non-target diseases. The study results suggest that beneficial non-specific effects, as observed for some other live-attenuated vaccines, may not apply to oral rotavirus vaccines, but studies in healthy term infants are needed to fur ther establish this.