Josephine van Dongen

7 Evaluation of implementing a targeted rotavirus vaccine program 165 Results Evaluation of the intervention Among 4958 screened infants in 13 hospitals post-implementation of the rotavirus vaccination program, 4621 had a GA of ≥ 27 weeks and were eligible for HRV vaccination. In total, 2370 infants were vaccinated with at least one HRV dose, resulting in overall mean vaccination coverage of 52.3% (95%CI 50.8-53.7%). The differences in coverage among types of MRC and hospitals (academic versus general) are presented in table 1 . Over time the vaccine coverage slightly improved, with a maximum between 6 and 12 months since implementation. The subset of infants par ticipating in the cohor t-study had a significant higher vaccination coverage compared to those not par ticipating ( table 1 ).Vaccination coverage per site ranged between 24.4% (95%CI 21.3;27.5%) and 83.4% (95%CI 79.9;87.0%). Timeliness of first dose HRV administration between six and nine weeks of age was 51.8% (1213/2340 infants), 2164 infants (92.5%, 95%CI 91.4;93.5%) were vaccinated within 14 weeks of age. For the second HRV dose limited information was available due to at home self-administration, 665 out of 772 infants (86.1%, 95%CI 83.7;88.6%) were vaccinated on time.There were no statistical significant differences in timeliness by type of medical risk group or type of hospital. Table 1 . Comparison of characteristics among HRV vaccinated and unvaccinated infants (GA ≥ 27 weeks) with medical risk conditions Vaccinated N=2370 Unvaccinated N=2162 p-value Type of MRC Premature SGA Premature and SGA Congenital pathology Premature and congenital pathology SGA and congenital pathology Premature, SGA and congenital pathology Bir thweight <2500 grams 1317 (58.3%) 144 (54.8%) 662 (57.5%) 89 (22.9%) 78 (36.4%) 31 (28.7%) 46 (33.1%) 2 (66.7%) 941 (41.7%) 119 (45.2%) 490 (42.5%) 299 (77.1%) 136 (63.6%) 7 7 (71.3%) 93 (66.9%) 1 (33.3%) 0.00 Hospital type Academic General 438 (28.2%) 1932 (64.9%) 1116 (71.8%) 1046 (35.1%) 0.00 Time since implementation