Josephine van Dongen

Chapter 2 32 Table 1 . Community AGE incidence for medical risk infants AGE Subgroup IR (per 100 PY) 95% CI p-value All cause 73.5 67.6 - 79.9 - Age < 6 months 48.3 39.8 – 58.3 - 6-12 months 85.7 75.3 – 97.1 0.00 > 12 months 79.3 68.4 – 90.1 0.43 Medical risk type Preterm (GA < 36 weeks) 75.9 68.0 – 84.6 - Preterm and SGA 64.0 52.4 – 77.2 0.13 Presence of congenital dis- order 66.9 51.5 – 86.8 0.44 Season Jan-Oct 94.5 85.6 – 104.1 - May-Sept 45.0 38.0 -53.0 0.00 Pathogen# Rotavirus 14.6 12.1 – 17.1 - Norovirus 14.2 11.7 – 16.7 0.89 Pan negative 31.7 28.6 – 34.8 0.00 # Estimated with correction for pathogen under detection based on multiple imputation for missing AGE samples. Abbreviations: AGE = acute gastroenteritis, IR = incidence rate, PY = person years, CI = confidence interval, GA = gestational age, SGA = small for gestational age, Jan = January, Dec = December. Healthcare was attended for 213 out of 559 of AGE episodes (38.1%, 95% CI 34 - 43%), 42 infants were admitted to the hospital for their AGE episode (7.5%). The propor tion of episodes requiring healthcare was twice as high for rotavirus- and norovirus positive episodes compared to pan negative episodes, p-value 0.00 (see Table 2 ). Nosocomial infections (based on acquiring infection during hospital stay) occurred in six patients.