Josephine van Dongen

3 Updated cost-effectiveness and risk-benefit analysis 59 Parameter Total popu- lation Non-tar- get group Target group Distribution Data source Method Rotavirus hospital- ization (€/ hospitaliza- tion) Calculated €2417 (2248– 2584) €2828 (2782– 4000) Per t RoHo study 11 Weighted esti- mates from original study data (see additional file in 11 ) Nosocomial rotavirus (€/ hospitaliza- tion) Calculated €2413 (1378– 3048) €2361 (1334– 3388) Uncompli- cated IS (€/ hospitaliza- tion) €1423 Fixed Hospital ad- ministrative data (see Additional file 1);Valk et al. 53 Average LOS for Dutch IS cases=2.11 days + costs of diagnostics (i.e., abdom- inal X-ray, ultrasonogra- phy) Complicat- ed IS (€/ hospitaliza- tion) €6759 Fixed Assumption 3× LOS for uncomplicated IS, whereof 1 day in ICU, and additional procedures (i.e., ileo-cecal resection, abdominal X-ray, ultra- sonography). See Additional file 1 Patient and family costs for rotavirus AGE b Without medical care Additional diapers Uniform Assumption For details see 11, 17 Requiring GP visit Additional diapers and travel costs Per t Assump- tions and guidelines for health economic evaluation 22 Hospitaliza- tion Travel costs Nosocomial rotavirus Not applicable