Josephine van Dongen

Chapter 3 80 Scenario ∆ QALY ∆ soc- ietal cost (in mio. €) a ICER (€/ QALY) - Societal perspec- tive ∆ health- care cost (in mio. €) a ICER (€/ QALY) - Health- care payer perspec- tive Induced IS/com- plicated IS cases Induced IS: prevent- ed fatal cases Induced IS: pre- vented hospital- ized cases Mean (95% CI) Mean (95% CI) Mean (95% CI) Mean (95% CI) Mean (95% CI) Mean (95% CI) Mean (95% CI) Mean (95% CI) Sensitivity and scenario analyses: w.r.t. assumed intussusception (IS) risk (in baseline 1:50,000) and compli- cated IS (in baseline 4.8%) IS risk: 1:20,000 1139 (426- 2022) -17.0 (-20.8-- 13.6) cost-sav- ing (cs-cs) -11.1 (-14.2- -8.4) cost-sav- ing (cs-cs) 11.53/ 0.55 1:9 (1:5- 1:13) 1:683 (1:598- 1:768) IS risk: 1:100,000 1139 (426- 2022) -17.0 (-20.8-- 13.6) cost-sav- ing (cs-cs) -11.1 (-14.2- -8.4) cost-sav- ing (cs-cs) 2.31/0.11 1:43 (1:23- 1:66) 1:3414 (1:2988- 1:3840) Compli- cated IS 0% 1139 (426- 2022) -17.0 (-20.8-- 13.6) cost-sav- ing (cs-cs) -11.1 (-14.2- -8.4) cost-sav- ing (cs-cs) 4.61/0.00 1:21 (1:12- 1:33) 1:1707 (1:1494- 1:1920) Compli- cated IS 9.6% 1139 (426- 2022) -17.0 (-20.8-- 13.6) cost-sav- ing (cs-cs) -11.1 (-14.2- -8.4) cost-sav- ing (cs-cs) 4.61/0.44 1:21 (1:12- 1:33) 1:1707 (1:1494- 1:1920) w.r.t. assumed hospitalization rate Lower hospital- ization rate (*75%) 870 (283- 1561) -11.5(- 14.5-- 8.9) cost-sav- ing (cs-cs) -6.9 (-9.2-- 4.8) cost-sav- ing (cs-cs) 4.61/0.22 1:16 (1:9- 1:25) 1:1,260 (1:1121- 1:1440) Higher hospital- ization rate (*125%) 1414 (566- 2482) -22.4 (-18.3-- 27.1) cost-sav- ing (cs-cs) -15.3 (-11.9-- 19.2) cost-sav- ing (cs-cs) 4.61/0.22 1:27 (1:15- 1:41) 1:2134 (1:1868- 1:2400) w.r.t. hospitalization costs Lower hospital- ization costs (*75%) 1139 (426- 2022) -13.0 (-16.0-- 10,2) cost-sav- ing (cs-cs) -7.1 (-9.4- -5.0) cost-sav- ing (cs-cs) 4.61/0.22 1:21 (1:12- 1:33) 1:1707 (1:1494- 1:1920) Higher hospital- ization costs (*125%) 1139 (426- 2022) -21.0 (-25.5- -17.0) cost-sav- ing (cs-cs) -15.1(- 19.0- -11.7) cost-sav- ing (cs-cs) 4.61/0.22 1:21 (1:12- 1:33) 1:1707 (1:1494- 1:1920)