Josephine van Dongen

Chapter 3 84 Scenario ∆ QALY ∆ soc- ietal cost (in mio. €) a ICER (€/ QALY) - Societal perspec- tive ∆ health- care cost (in mio. €) a ICER (€/ QALY)- Health- care payer perspec- tive Induced IS/com- plicated IS cases Induced IS: prevent- ed fatal cases Induced IS: pre- vented hospi- talized cases Mean (95% CI) Mean (95% CI) Mean (95% CI) Mean (95% CI) Mean (95% CI) Mean (95% CI) Mean (95% CI) Mean (95% CI) Higher hospital- ization costs (*125%) 1907 (1114- 2915) 79 (54-100) 41,531 (22,321- 79,488) 119 (105- 132) 62,275 (38,511- 111,246) 58.4 / 2.8 1:1.8 (1:1.0- 1:2.8) 1:685 (1:603- 1:767) w.r.t. productivity losses Higher prouctiv- ity losses (* 200%) 1907 (1114- 2915) 60 (20-88) 31,659 (9,010- 65,904) 137 (126- 148) 72,027 (45,106- 126,931) 58.4 / 2.8 1:1.8 (1:1.0- 1:2.8) 1:685 (1:603- 1:767) Caregiver work loss as in 8 b 1907 (1114- 2915) 99 (83-114) 51,746 (30,863- 94,173) 137 (126- 148) 72,021 (45,102- 126,919) 58.4 / 2.8 1:1.8 (1:1.0- 1:2.8) 1:685 (1:603- 1:767) w.r.t. assumed QALY losses (in baseline: 0.0011, 0.0022, 0.0034 and 0.0026 for mild, moderate, severe and nosocomical infections, respectively) QALY losses as in 8 c 1875 (1083- 2882) 98 (74-116) 52,165 (29,599- 97,158) 137 (126- 148) 73,268 (45,633- 130,334) 58.4 / 2.8 1:1.8 (1:1.0- 1:2.8) 1:685 (1:603- 1:767) higher QALY losses 9 d 2144 (1332- 3179) 98 (74-116) 45,620 (26,919- 80,560) 137 (126- 148) 64,075 (41,500- 106,594) 58.4 / 2.8 1:1.8 (1:1.0- 1:2.8) 1:685 (1:603- 1:767) w.r.t. assumed discount rate (3% for costs and effects in baseline) Discount rate: 0% effects & costs 3525 (1715- 5891) 126 (95-150) 35,747 (18,828- 77,207) 178 (163- 192) 50,537 (29,130- 104,921) 58.4 / 2.8 1:1.8 (1:1.0- 1:2.8) 1:685 (1:603- 1:767) Discount rate: 2% effects & costs 2294 (1279- 3612) 106 (80-126) 46,192 (25,696- 88,889) 149 (137- 161) 65,025 (39,734- 119,999) 58.4 / 2.8 1:1.8 (1:1.0- 1:2.8) 1:685 (1:603- 1:767) Discount rate: 4% effects & costs 1612 (976- 2416) 91 (69-108) 56,223 (32,908- 101,064) 127 (117- 137) 78,785 (50,448- 133,670) 58.4 / 2.8 1:1.8 (1:1.0- 1:2.8) 1:685 (1:603- 1:767)