Josephine van Dongen

3 Updated cost-effectiveness and risk-benefit analysis 87 0 to 4; 5 to 9 and 10 to 14 years respectively versus in the baseline: 1 day (~8 hours) in 5% of episodes for children under the age of 10 and for children > 10 years of age work loss estimates were reduced by 50%. In the earlier model the assumed hours of work loss for moderate cases were: 1.35; 1.98; 1.23 for ages 0 to 4; 5 to 9 and 10 to 14 years respectively versus in the baseline: 0.5 – 2 days in 25% of episodes for children under the age of 10 and for children > 10 years of age work loss estimates were reduced by 50%. c)Bruijning et al 8 used 0.0011, 0.0022, 0.0022 and 0.0020 for mild, moderate, severe and nosocomial infections, respectively. d)We included slightly higher QALY losses based on the sensitivity analysis of Marlow et al. (for hospital- izations 0.0039 vs 0.0030 in the baseline and for GP visits 0.0030 vs 0.0022 in the baseline) 9 ). e) On average 21.5% of the 0-1 years old would require a GP visit, whereas only 18.5% of 1-4 years old ( Table 1 ). As the GP has a gatekeeper function in the Netherlands, we modelled that on av- erage 27.6% of the 0-1 year olds visiting a GP would require hospitalization, whereas this would be only 16.4% if 1-4 years old.These averages were derived from the baseline simulations results. Table S4 – Universal vaccination compared to target vaccination: Baseline assumptions and applied sensitivity and scenario analyses Scenario ∆ QALY ∆ soc- ietal cost (in mio. €) a ICER (€/ QALY) - Societal perspec- tive ∆ health- care cost (in mio. €) ICER (€/ QALY)- Health- care payer perspec- tive Induced IS/com- plicated IS cases Induced IS: prevent- ed fatal cases Induced IS: pre- vented hospi- talized cases Mean (95% CI) Mean (95% CI) Mean (95% CI) Mean (95% CI) Mean (95% CI) Mean (95% CI) Mean (95% CI) Mean (95% CI) Baseline 769 (561- 1003) 115 (94- 131) 149,282 (101,101 - 220,113) 148 (139- 157) 193,084 (142,802 - 271,403) 53.8/ 2.6 1:0.09 (1:0.02- 1:0.2) 1:597 (1:526- 1:668) Sensitivity and scenario analyses: w.r.t. vaccine cost per child, excluding application costs (in baseline vaccine costs of €75/child) Vaccine costs of €67.5 769 (561- 1003) 98 (77-114) 127,021 (82,989- 190,334) 131 (122- 140) 170,823 (125,657 - 241,489) 53.8/ 2.6 1:0.09 (1:0.02- 1:0.2) 1:597 (1:526- 1:668) Vaccine costs of €60.0 769 (561- 1003) 81 (59-97) 104,760 (65,365- 161,065) 114 (105- 123) 148,562 (108,357 - 211,313) 53.8/ 2.6 1:0.09 (1:0.02- 1:0.2) 1:597 (1:526- 1:668) Vaccine costs of €52.5 769 (561- 1003) 63 (42-79) 82,500 (47,090- 131,537) 97 (88-106) 126,301 (91,196- 181,116) 53.8/ 2.6 1:0.09 (1:0.02- 1:0.2) 1:597 (1:526- 1:668) Vaccine costs of €45.0 769 (561- 1003) 46 (25-62) 60,239 (28,385- 101,948) 80 (71-89) 104,040 (73,947- 151,104) 53.8/ 2.6 1:0.09 (1:0.02- 1:0.2) 1:597 (1:526- 1:668)