151751-Najiba-Chargi

101 Surgery: skeletal muscle mass and free fibula flap reconstruction Table 3. Univariate and multivariate Cox regression analysis: overall survival and disease-free survival OVERALL SURVIVAL DISEASE-FREE SURVIVAL Variables Univariate Multivariate Univariate Multivariate HR 95% CI p-value HR 95% CI p-value HR 95%CI p-value HR 95% CI p-value Low SMM 2.2 1.1-4.5 0.03* 2.4 1.1-5.1 0.02* 2.0 0.8-4.8 0.12 1.9 0.8-4.6 0.18 Age (years) 1.0 1.0-1.1 0.41 1.0 1.0-1.0 0.90 1.0 1.0-1.0 0.73 1.0 1.0-1.0 0.98 Adult Comorbidity Evaluation-27 None Mild Moderate Severe Ref 3.3 2.4 1.9 1.3-8.4 1.0-5.5 0.4-9.1 0.01* 0.04* 0.41 Ref 3.3 2.5 1.6 1.2-9.2 1.2-6.1 0.3-7.4 0.02* 0.05 0.58 Ref 1.5 1.5 1.0 0.5-4.2 0.6-3.7 0.1-7.8 0.48 0.43 0.98 Ref 1.3 1.4 0.8 0.4-4.1 0.5-3.8 0.1-6.8 0.69 0.47 0.88 TNM stage I II III IV Ref 0.2 1.0 0.4 0.0-3.5 0.0-∞ 0.1-3.3 0.29 0.98 0.44 Ref 0.5 - 1.0 0.0-8.7 - 0.1-8.0 0.61 - 1.00 Ref 0.4 - 0.4 0.0-6.7 - 0.1-2.9 0.54 - 0.35 Ref 0.60 - 0.50 0.0-11.8 - 0.1-4.4 0.73 0.54 6