151751-Najiba-Chargi

126 CHAPTER 7 Table 3. (Continued) Variable Univariate analysis OR 95% CI p-value Multivariate analysis OR 95% CI p-value BMI (kg/m 2 ) Normal (18.5 - 24.9) Underweight (≤ 18.5) Overweight (25 - 29.9) Obese (≥ 30) Ref. 0.5 0.7 1.7 0.1 - 2.0 0.3 - 1.8 0.5 - 5.7 0.3 0.5 0.4 Smoking status Never Current/former Ref. 1.0 0.5 - 2.2 1.0 Alcohol use Never Current/former Ref. 0.9 0.4 - 1.9 0.7 Low hemoglobin , ≤ 100 g/L No Yes Ref. 1.8 0.6 - 5.7 0.3 Elevated NLR , > 3 No Yes Ref. 1.2 0.5 - 2.6 0.7 Low albumin , ≤ 40 g/L No Yes Ref. 1.1 0.4 - 2.8 0.8 Low SMM ** No Yes Ref. 1.4 0.6 - 3.0 0.5 SMM and NLR Normal SMM and NLR Normal NLR, low SMM Normal SMM, NLR > 3 Low SMM and NLR > 3 Ref. 2.7 2.3 1.9 0.8 - 9.2 0.7 - 7.7 0.6 - 6.0 0.1 0.2 0.3 Ref. 2.1 2.0 1.6 0.6 - 7.7 0.6 - 7.0 0.5 - 5.2 0.2 0.3 0.5 *Due to unknown alcohol and smoking status of 40 patients, imputation analysis was performed. **Low SMM defined as LSMI ≤43.2cm/m 2 When performingmultivariate analysis to distinguish predictors for flap-related complications in oncological patients, combined elevated NLR with normal SMM was predictive for flap-re- lated complications (OR 3.0; 95% CI 1.2-7.5, p=0.02) independent of hemoglobin levels (OR 1.1; 95%CI 1.0-1.0, p=0.3) and BMI (OR 1.0; 95%CI 0.3-2.8, p=0.5) and for severe complications (Clavien-Dindo grade ≥ 3b) (OR 2.2; 95%CI 1.1-4.5, p=0.04) independent of hemoglobin levels (OR 1.0, 1.0-1.0, p=0.04) and patients’ comorbidities (ORmild 1.3, ORmoderate 1.1, OR severe 1.4, all p>0.05). LENGTH OF HOSPITAL STAY Median LOS for all included patients was 13 days with an IQR of 11-18 days. When comparing mean LOS between patients with and without low SMM, patients with low SMM had longer