151751-Najiba-Chargi

130 CHAPTER 7 Table 4. (Continued) Variable Univariate analysis HR 95% CI p-value Multivariate analysis 1 HR 95% CI p-value Multivariate analysis 2 HR 95% CI p-value Oncological HNSCC patients: TNM stage I-II - DFS Gender Female Male Ref. 0.4 0.2-0.8 0.02 Ref. 0.5 0.2-1.0 0 .06 Age (years ) 1.1 1.01-1.1 0.001 1.04 1.01-1.08 0.007 ACE-27 None Mild Moderate Severe Ref. 0.8 2.2 1.3 0.4-1.9 0.9-5.5 0.2-9.7 0.7 0.09 0.8 Ref. 0.9 1.9 1.4 0.4-1.9 0.8-4.8 0.2-10.7 0.7 0.2 0.7 Ref. 0.9 2.2 1.0 0.4-2.0 0.9-5.6 0.1-7.8 0.8 0.09 0.99 BMI (kg/m 2 ) 0.95 0.9-1.0 0.2 Hemoglobin (g/L) 0.99 0.9-1.0 0.4 Hemoglobin ≤100 (g/L) No Yes Ref 0.05 0-µ 0.7 NLR ≤ 3.0 3.0 Ref. 1.2 0.6-2.4 0.6 Low SMM No Yes Ref. 2.2 1.0-5.0 0.05 Ref. 2.0 0.9-4.6 0.09 SMM and NLR Normal SMM and NLR Normal NLR, low SMM Normal SMM, NLR>3 Low SMM and NLR>3 Ref. 3.4 2.2 3.3 1.0-11.8 0.5-9.1 0.9-12.1 0.06 0.3 0.07 Oncological HNSCC patients: TNM stage III-IV - DFS Gender Female Male Ref. 1.0 0.7-1.5 0.9 Age (years) 0.98 0.97-1.0 0.05 0.98 0.96-0.99 0.03 0.98 0.96-0.99 0.02 ACE-27 None Mild Moderate Severe Ref. 0.8 1.0 0.3 0.5-1.2 0.6-1.8 0.04-2.0 0.2 1.0 0.2 BMI (kg/m 2 ) 0.9 0.9-1.0 0.2 Hemoglobin (g/L) 0.9 0.9-1.0 0.1 0.99 0.98-1.0 0.07