151751-Najiba-Chargi

142 CHAPTER 8 ABSTRACT Background Low skeletal musclemass, also referred to as sarcopenia, is associatedwith negative outcomes in oncology. The aim of this study was to investigate the predictive impact of sarcopenia on perioperative complication rate in patients with oral squamous cell carcinoma (OSCC). Material and methods Patients who had been operated between 2014 and 2017 for OSCC were included. Data were extracted from electronic medical records. The cross-sectional muscle area at the level of the third lumbar vertebra (L3) was estimated from a single CT-slice at the level of the third cervical vertebra (C3) and divided by squared body height to calculate the lumbar skeletal muscle index (LSMI). Sarcopenia was defined as the lowest quartile LSMI of the patient group. Univariate and multivariate analyses were used to test sarcopenia as an independent risk factor for perioperative complication rate. Results In total, 226 patients were included of which 51 patients had developed 81 complications. In multivariate analysis, the presence and number of perioperative complications was re- spectively associated with sarcopenia (OR 2.6, p<0.05) (OR 2.4, p<0.05), longer operating time (OR 1.4, p<0.01) (OR 1.2, p<0.01), increased blood loss (OR 1.5, p<0.01) (OR 1.6, p<0.01) and comorbidity (OR 9.1, p<0.01) (OR 6.2, p<0.01). Longer hospital stay was associated with longer operating time (OR 1.04, p<0.01), decrease in hemoglobin level (OR 1.04, p<0.01) and ASA (score 3) (OR 1.1, p<0.01) Conclusion Sarcopenia is an independent risk factor for perioperative complication rate in OSCC patients undergoing surgical treatment.