151751-Najiba-Chargi

166 CHAPTER 9 Table 4. Multivariable logistic regression analysis for arterial calcification as a risk factor for pharyngocutaneous fistula Anatomical location of arterial calcification Score a Adjusted OR 1 b (95% CI) P value Adjusted OR 2 c (95% CI) P value Ascending aorta 0 1 Ref 1.66 (0.91 - 3.02) 0.10 Ref 2.27 (1.16 - 4.46) 0.02 Aortic arch 0 1 Ref 1.21 (0.61 - 2.41) 0.58 Ref 1.21 (0.61 - 2.41) 0.59 Descending aorta 0 1 Ref 2.80 (1.38 - 5.66) <0.01 Ref 2.07 (1.07 - 3.99) 0.03 Origo of the brachiocephalic arteries 0 1 Ref 2.09 (1.02 - 4.27) 0.04 Ref 2.28 (1.05 - 4.92) 0.04 Left extracranial carotid artery 0 1 Ref 1.19 (0.57 - 2.48) 0.64 Ref 0.92 (0.45 - 1.89) 0.82 Right extracranial carotid artery 0 1 Ref 2.17 (1.08 - 4.39) 0.03 Ref 1.84 (0.87 - 3.89) 0.11 Left vertebral artery 0 1 Ref 0.33 (0.11 - 1.01) 0.05 Ref 0.40 (0.13 - 1.25) 0.12 Right vertebral artery 0 1 Ref 0.56 (0.20 - 1.59) 0.28 Ref 0.69 (0.23 - 2.03) 0.50 Left carotid siphon 0 1 Ref 2.83 (1.32 - 6.08) 0.01 Ref 2.21 (1.04 - 4.69) 0.04 Right carotid siphon 0 1 Ref 1.83 (0.94 - 3.57) 0.08 Ref 1.82 (0.90 - 3.69) 0.10 Total arterial calcification score Cont.d 1.08 (1.02 - 1.15) 0.01 1.06 (1.01 - 1.12) 0.03 Numbers in bold: significant at the level of p ≤ 0.05, a Score: 0 - none to mild; 1 - moderate to severe, b Multivariate analysis 1: Corrected for: age at diagnosis, BMI, sarcopenia, smoking, alcohol abuse and ASA classification as a surrogate for comorbidities, c Multivariate analysis 2: Corrected for preoperative risk factors: localization of tumor, indication for total laryngectomy (primary, salvage or dysfunctional larynx), additional lymph node dissection, extent of pharyngeal resection and closing method of neopharynx, d Continuous: score between 0 and 30 In the first model, arterial calcification of the descending aorta (OR 2.80 [1.38 - 5.66], p < 0.01), origo of the brachiocephalic arteries (OR 2.09 [1.02 - 4.27], p = 0.04), right extracranial carotid artery (OR 2.17 [1.08 - 4.39], p = 0.03) and left carotid siphon (OR 2.83 [1.32 - 6.08], p = 0.01) remained significantly associated with the occurrence of a pharyngocutaneous fistula. In the second model, arterial calcification of the ascending aorta (OR 2.27 [1.16 - 4.46], p = 0.02), descending aorta (OR 2.07 [1.07 - 3.99], p = 0.03), origo of the brachiocephalic arteries (OR 2.28 [1.05 - 4.92], p = 0.04) and left carotid siphon (OR 2.21 [1.04 - 4.69], p = 0.04) were significantly associated with the occurrence of a pharyngocutaneous fistula. A higher total arterial calcifi - cation score was significantly associated with PCF formation in the first (OR 1.08 [1.02 - 1.15], p = 0.01) and the second (OR 1.06 [1.01 - 1.12], p = 0.03) multivariable model.