151751-Najiba-Chargi

167 Surgery: skeletal muscle mass, arterial calcification and laryngectomy ARTERIAL CALCIFICATION AND SARCOPENIA As there may be a shared etiological factor in atherosclerosis and sarcopenia, the occurrence of arterial calcification in patients with and without sarcopenia was explored. Data are shown in Supplementary Data Table 1. Moderate to severe arterial calcification at the location of the descending aorta was signifi- cantly more often present in patients with sarcopenia as compared to patients without sarco - penia (Pearson Chi square test: p < 0.01). At the other locations, no significant difference was observed. The association between arterial calcification and sarcopenia as independent risk factors for PCF formation is shown in Supplementary Data Table 2. In multivariable logistic regression analysis, both the total arterial calcification score (adjusted OR 1.05 [1.00 - 1.10], p = 0.04) and sarcopenia (adjusted OR 1.86 (1.02 - 3.39), p = 0.04) are independently associated with PCF formation. Supplementary table 1 : Presence of arterial calcification and sarcopenia Anatomical location of arterial calcification Score a Sarcopenia (n = 103) Normal skeletal muscle mass (n = 121) P value Ascending aorta 0 1 60 43 72 49 0.85b Aortic arch 0 1 32 71 44 77 0.40b Descending aorta 0 1 36 67 69 52 <0.01 b Origo of the brachiocephalic arteries 0 1 28 75 39 82 0.41b Left extracranial carotid artery 0 1 28 75 34 87 0.88b Right extracranial carotid artery 0 1 35 68 35 86 0.42b Left vertebral artery 0 1 87 16 107 14 0.39b Right vertebral artery 0 1 90 13 108 13 0.66b Left carotid siphon 0 1 30 73 39 82 0.62b Right carotid siphon 0 1 33 70 42 79 0.67b Total arterial calcification scored Mean SD 16.5 7.4 15.1 6.8 0.09c Numbers in bold: significant at the level of p ≤0.05, a Score: 0 - none to mild; 1 - moderate to severe, b Pearson Chi square test, c Mann-Whitney U test, d Continuous; score between 0 and 30 9