151751-Najiba-Chargi

204 CHAPTER 11 Table 1. (Continued) Characteristic Total patients n = 153 (%) Patients with CDLT n = 37 (%) Without CDLT n = 116 (%) P value III 66 (43.1) 14 (37.8) 52 (44.8) IV 83 (54.2) 23 (62.2) 60 (51.7) Extracapsular extension No 109 (71.2) 29 (78.4) 80 (69.0) 0.27* Yes 44 (28.8) 8 (21.6) 36 (31.0) Number of cisplatin cycles 1 37 (24.2) 37 (100) - n/a 2 35 (22.9) - 35 (30.2) 3 81 (52.9) - 81 (69.8) CDLT Absent 116 (75.8) - 116 (100) n/a Present 37 (24.2) 37 (100) Survival status Alive 99 (64.7) 21 (56.8) 78 (67.2) 0.25* Deceased 54 (35.3) 16 (43.2) 38 (32.8) * Fisher’s exact test, # Pearson Chi square test, $ Independent student’s T test LOW SMM AS A PREDICTOR FOR CDLT A sex-specific cut-off point for low SMM as a predictor for CDLT was formulated using a ROC curve. The AUC of the ROC curve was 0.72 for women (Mann-Whitney U test: p = 0.05) and 0.58 for men (Mann-Whitney U test: p = 0.11). The optimal cut-off value for low SMM was 10.7 cm 2 for women and 13.1 cm 2 for men. Using this cut-off, 54.9% of patients had low SMM. UNIVARIATE AND MULTIVARIATE ANALYSIS FOR CDLT Table 2 shows patient and disease characteristics of patients with low SMM and normal SMM. Patients with low SMM had a significantly lower BMI (p < 0.01) and a higher T stage (p = 0.05) and showed a trend towards a higher N stage (p = 0.09). There were no significant differences in terms of gender or age of patients with and without low SMM. Patients with low SMM expe - rienced CDLT significantly more often than patients with normal SMM (35.7% versus 10.1%; p < 0.01). In table 3, the univariate and multivariate analysis for the occurrence of CDLT are shown. In univariate analysis, only low SMM (OR 3.75 [95% CI 1.58 – 8.90], p < 0.01) and a mild renal function impairment with an eGFR of 60 – 70 (OR 3.82 [95% CI 1.23 – 11.81], p = 0.02) were associated with the occurrence of CDLT. In multivariate analysis, both low SMM (OR 3.99 [95% CI 1.56 – 10.23], p = 0.01) and a mild renal function impairment (OR 5.40 [95% CI 1.57 – 18.65], p < 0.01) remained associated with the occurrence of CDLT.