151751-Najiba-Chargi

206 CHAPTER 11 Table 3. Univariate and multivariate logistic regression analysis for prediction of CDLT Univariate analysis Multivariate analysis Odds Ratio (95% CI) p-value Odds Ratio (95% CI) p-value Gender Male Female Ref 0.84 (0.36 - 1.98) 0.70 Age at diagnosis (years) 1.04 (0.98 – 1.10) 0.20 BMI at diagnosis (kg/m 2 ) 0.99 (0.90 – 1.08) 0.82 Tumor site Oropharynx HPV+ Oropharynx HPV-/unknown Hypopharynx Larynx Ref 1.09 (0.41 – 2.92) 2.96 (0.72 - 12.00) 1.00 (0.37 - 2.72) 0.86 0.13 1.00 AJCC stage II-III IV Ref 1.53 (0.72 - 3.27) 0.27 Renal function eGFR >70 eGFR 60-70 Ref 3.82 (1.23 - 11.81) 0.02 Ref 5.40 (1.57 - 18.65) < 0.01 Low SMM No Yes Ref 3.75 (1.58 - 8.90) < 0.01 Ref 3.99 (1.56 - 10.23) 0.01 ACE-27 score 0 1 or 2 Ref 0.96 (0.41 - 2.28) 0.94 Smoking No Former Active Ref 2.40 (0.59 - 9.82) 1.21 (0.41 - 3.54) 0.22 0.73 Bold p-value indicates a significant difference between groups.