151751-Najiba-Chargi

223 Systemic therapy: skeletal muscle mass and bioradiotherapy CHARACTERISTICS OF STUDY POPULATION Table 1 shows the general characteristics of the study population according to the presence or absence of low SMM. Significant differences were observed for the occurrence of low SMM in the presence of weight loss six months prior to diagnosis, sex, and body mass index. Patients with low SMM were more likely to be female (35.3% versus 4.3%; χ 2  = 8.26; p = 0.002), more likely to have experienced weight loss in the six months prior to diagnosis (50.0% versus 17.4%; MH χ 2  = 9.32; p = 0.01) and were less likely to be overweight (BMI 25-29.9) (16.2% versus 39.1%; MH χ 2 = 45.88; p < 0.001) or obese (BMI ≥ 30) (2.9% versus 52.2%; MH χ 2 = 45.88; p < 0.001). Table 1. General characteristics of the study population according to presence or absence of low SMM Low SMM Without low SMM n 68 (74.7%) 23 (25.3%) n (%) or mean(±SD) n (%) or mean(±SD) p-value a Gender Female Male 24 (35.3%) 44 (64.7%) 1 (4.3%) 22 (95.7%) 0.002** Age at diagnosis 62.18 (±7.22) 63.33 (±7.78) 0.52 Weight loss 6 months prior None ≤ 10% > 10% 34 (50.0%) 17 (25.0%) 17 (25.0%) 19 (82.6%) 4 (17.4%) 0 (0.0%) 0.008* Body Mass Index (kg/m 2 ) < 20 20-24.9 25-29.9 ≥ 30 29 (42.6%) 26 (38.2%) 11 (16.2%) 2 (2.9%) 0 (0%) 2 (8.7%) 9 (39.1%) 12 (52.2%) <0.001** Smoking status Non-smoker Former-Smoker Smoker 2 (2.9%) 23 (33.8%) 43 (63.2%) 3 (13.0%) 8 (34.8%) 12 (52.2%) 0.19 Pack-Years 0 1-15 16-25 26-40 ≥ 41 2 (3.4%) 8 (13.6%) 9 (15.3%) 17 (28.8%) 23 (39.0%) 3 (14.3%) 2 (9.5%) 5 (23.8%) 6 (28.6%) 5 (23.8%) 0.62 Alcohol use No Former Yes 5 (8.5%) 11 (18.6%) 43 (72.9%) 5 (15.6%) 2 6.3%) 25 (78.1%) 0.21 Alcohol(U/day) 4.25 (±4.19) 2.38 (±1.69) 0.05 12