151751-Najiba-Chargi

225 Systemic therapy: skeletal muscle mass and bioradiotherapy multivariate Cox regression analysis for the association with cetuximab DLT included weight loss, ACE- 27 score, and low SMM. These variables were chosen because of their clinical signif - icance or statistical significance in the univariate analysis. Both weight loss six months prior to diagnosis and ACE-27 score showed statistically significant predictive value for cetuximab DLT in this multivariate analysis. Low SMM remained non-significant in multivariate analysis (OR 0.83; 95% CI 0.27-2.56; p = 0.74). Table 2. Univariate and multivariate analysis of predictive factors for cetuximab dose-limiting toxicity Variable Cetuximab dose-limiting toxicity Univariate analysis a Multivariate analysis b OR 95% CI p-value OR 95% CI p-value Gender 0.44 0.17-1.18 0.1 Age 1.02 0.96-1.08 0.55 Weight loss 6 months prior None ≤ 10% > 10% Ref. 0.24 0.30 0.06–0.90 0.08-1.18 0.03* 0.09 Ref. 0.20 0.31 0.05-0.87 0.07-1.41 0.03* 0.13 Body Mass Index (kg/m 2 ) 20-24.9 < 20 25-29.9 ≥ 30 Ref. 1.35 2.50 0.82 0.44-4.32 0.72-8.38 0.18-3.80 0.61 0.15 0.80 Smoking status Non-smoker Smoker Former-Smoker Ref. 0.56 0.83 0.09-3.71 0.12-5.71 0.56 0.85 Alcohol use No Yes Former Ref. 1.04 1.04 0.25-4.43 0.17-6.23 1.0 1.0 Alcohol(U/day) 0.93 0.80-1.07 0.3 ACE-27 score c None Mild Moderate Severe Ref. 0.19 0.13 0.12 0.02-0.75 0.02-0.74 0.02-0.72 0.02* 0.02* 0.02* Ref. 0.09 0.09 0.10 0.01-0.67 0.01-0.64 0.02-0.74 0.02* 0.02* 0.02* HPV-status d 0.90 0.22-3.74 0.89 Low SMM 0.60 0.22-1.63 0.32 0.83 0.27-2.56 0.74 a Logistic regression analysis, b Multivariate logistic regression (Backward Wald model, c ACE-27 = Adult Comorbidity Evaluation, d HPV = Human Papillomavirus, ** Correlation is significant at the 0.01 level (2- tailed), * Correlation is significant at the 0.05 level (2-tailed) Table 3 shows the univariate and multivariate Cox regression analysis for the association with OS. The univariate analysis showed that weight loss six months prior to diagnosis, HPV status, 12