151751-Najiba-Chargi

226 CHAPTER 12 alcohol units per day, and low SMM are statistically significant prognostic factors for OS. These statistically significant prognostic factors of the univariate analysis were used in the multi- variate analysis. BMI was close to statistically significant (HR 0.43; 95% CI 0.18-1.01; p = 0.05), therefore, BMI was added into the multivariate analysis. With weight loss, BMI, HPV status, alcohol units per day, and low SMM entered into the multivariate analysis, the two statistically significant prognostic factors were weight loss of more than 10% prior to diagnosis (HR 3.66; 95%CI 1.66-8.09; p = 0.001) and positive HPV status (HR 0.24; 95%CI 0.07-0.85; p = 0.03). Low SMM showed no statistically significant prognostic value in the multivariate analysis (HR 1.48; 95% CI 0.48-4.58; p = 0.50). Table 3. Univariate and multivariate analysis of prognostic factors for overall survival Variable Overall Survival Univariate analysis a Multivariate analysis b HR 95% CI p-value HR 95% CI p-value Gender 0.10 0.88-3.20 0.11 Age 0.97 0.94-1.01 0.14 Weight loss 6 months prior None ≤ 10% > 10% Ref. 1.68 3.41 0.87-3.24 1.79-6.50 0.12 0.001** Ref. 1.60 3.66 0.78-3.27 1.66-8.09 0.20 0.001** Body Mass Index (kg/m 2 ) 20-24.9 < 20 25-29.9 ≥ 30 Ref. 1.56 0.43 0.59 0.85-2.88 0.18-1.01 0.24-1.49 0.15 0.05 0.27 Ref. 0.96 0.70 0.70 0.49-1.98 0.34-2.06 0.31-5.63 0.96 0.70 0.70 Smoking status Non-smoker Smoker Former-Smoker Ref. 6.59 2.78 0.90-48.41 0.36-21.32 0.06 0.33 Alcohol(U/day) 1.08 1.02 0.013* 1.04 0.97-1.11 0.30 ACE-27 score c None Mild Moderate Severe Ref. 1.78 2.74 2.32 0.5-6.39 0.82-9.19 0.66-8.18 0.38 0.10 0.19 TNM-stage Stage 1 Stage 2 Stage 3 Stage 4 Ref. 0.60 0.42 0.99 0.05-6.73 0.05-3.62 0.14-7.20 0.70 0.43 0.99 HPV status d 0.14 0.03-0.58 0.007** 0.24 0.07-0.85 0.03* Low SMM 2.45 1.16-5.19 0.019* 1.48 0.48-4.58 0.50 a Cox regression analysis, b Multivariate cox regression (Backward Wald model), c ACE-27 = Adult Comorbidity Evaluation, d HPV = Human Papillomavirus, ** Correlation is significant at the 0.01 level (2-tailed), * Correlation is significant at the 0.05 level (2-tailed)