151751-Najiba-Chargi

236 CHAPTER 13 ABSTRACT Background Low skeletal muscle mass (SMM) is increasingly recognized for its predictive value for adverse events in cancer patients. In specific, the predictive value of low SMM has been demonstrated for anti-cancer drug toxicity in a variety of cancer types and anti-cancer drugs. However, due to the limited sample size and study populations focused on a single cancer type, an overall predictive value of low SMM for anti-cancer drug toxicity remains unknown. Therefore, this review aims to provide a comprehensive overview of the predictive value of low SMM and perform a meta-analysis to analyse the overall effect. Material and methods A systematic search was conducted of MEDLINE, Scopus, EMBASE, and Cochrane. Inclusion criteria were skeletal muscle mass (SMM) evaluated with computed tomography (CT) or mag - netic resonance imaging (MRI), articles published in English, SMM studied in humans, SMM measurement normalized for height, and patients did not receive an intervention to treat or prevent low SMM. A meta-analysis was performed using a random-effects model and ex - pressed in odds ratio (OR) with 95% confidence interval (CI). Heterogeneity was assessed using χ 2 and I2 statistics. Results The search yielded 907 studies. 31 studies were included in the systematic review. Sample sizes ranged from 21 to 414 patients. The occurrence of low SMM ranged from 12.2% to 89.0%. The most frequently studied cancer types were oesophageal, renal, colorectal, breast, and head and neck cancer. Patients with low SMM had a higher risk of severe toxicity (OR 4.08; 95% CI 2.48–6.70; p < 0.001) and dose-limiting toxicity (OR 2.24; 95%CI 1.28–3.92; p < 0.001) compared to patients without low SMM. Conclusion To conclude, the predictive value of low SMM for anti-cancer drug toxicity can be observed across cancer types. This information increases the need for further research into interven - tions that could treat low SMM as well as the possibility to adapt treatment regimens based on the presence of low SMM.