151751-Najiba-Chargi

244 CHAPTER 13 Figure 2. Quality in Prognostic Studies (QUIPS) for the included studies. a. DLT (dose-limiting toxicity): toxicity leading todose reduction, treatment delay, or discontinuation. b. Occurrence of DLT for CAPOX-B and CAP-B respectively. c. Occurrence of dose delay and dose reduction respectively. Definitions of low SMM 1. Prado et al. 2008 46 : <52.4 cm 2 /m 2 for men and <38.5 cm 2 /m 2 for women 2. Martin et al. 2013 47 : <43 cm 2 /m 2 for men if BMI ≤24.9 kg/m 2 or <53cm 2 /m2 for men if BMI >25kg/m 2 and <41 cm 2 /m 2 for women 48 3. 25th percentile < 44.8cm 2/ m 2 vs 75th percentile >63.2cm 2/ m 2 4. Fujiwara et al. 2015 48 : ≤36.2 cm 2 /m 2 for men and ≤29.6 cm 2 /m 2 for women 5. Caan et al. 2018 49 : <40 cm 2 /m 2