151751-Najiba-Chargi

246 CHAPTER 13 Figure 3. Forest plots for the association between low skeletal muscle mass (LOW SMM) and the odds to develop anti-cancer drug toxicity, specifically dose-limiting toxicity (DLT). (A) shows the odds to develop toxicity for all included studies with DLT as the toxicity endpoint. (B) shows the odds to develop DLT for a selected group of studies that besides the same toxicity endpoint also share the same cut-off value established by Martin et al., 2013 47, as well as the same measurement technique using CT at the L3 vertebrae. (C) shows the odds to develop DLT for a second selected group of studies that share the same cut-off value established by Prado et al., 2008 46, as well as the same measurement technique using CT at the L3 vertebrae. For each forest plot, the combined effect of the studies is plotted with a black diamond. * The patient population in the study by Kurk et al., 2019, received sequential treatments. The odds ratio was determined for each treatment separately and therefore entered separately into the forest plot.