151751-Najiba-Chargi

282 CHAPTER 15 PREDICTORS OF LOSS IN SKELETAL MUSCLE MASS Table 4 shows the Cox regression analysis of the predictors for loss of SMM. In univariate regression analysis, significant predictors for loss of SMM were a BMI ≥25kg/m 2 (hazard ratio (HR) 1.7, 95% confidence interval (CI) 1.1-2.6), blood albumin levels (HR 1.1, 95% CI 1.0-1.2), a tumor located in the oropharynx (HR 2.6, 95%CI 1.7-4.0), nasopharynx (HR 2.5, 95%CI 1.3-5.0) or larynx (HR 2.9; 95%CI 1.2-6.9). Having an ECOG performance status of 1 was associated with a lower risk of loss of SMM (HR 0.5, 95% CI 0.3-0.7) compared to patients with ECOG 0. Under - going CRT in a postoperative setting was also associated with a lower risk of loss in SMM (HR 0.5; 95% CI 0.3-0.7). Patients able to receive an absolute cumulative cisplatin dose of ≥300mg were also less likely to experience loss of SMM (HR 0.6, 95% CI 0.4-0.97). In multivariate Cox regression analysis including the variables BMI, albumin levels, tumor site, treatment setting and received cisplatin dose; a BMI ≥25kg/m 2 or BMI ≥30kg/m 2 (HR 2.4, 95% CI 1.3-4.6 and HR 3.1, 95% CI 1.3-7.3, respectively), albumin level (HR 1.1, 95% CI 1.1-1.2), a tumor located in the oropharynx (HR 2.4, 95% CI 1.2-4.8), receiving CRT in an adjuvant setting (HR 0.4, 95% CI 0.2- 0.8) remained significant predictors for loss of SMM after CRT. Table 4. Proportional Cox regression analysis: predictors for SMM loss Univariate analysis Multivariate analysis HR (95% CI) p-value HR (95% CI) p-value Age (years) (mean, SD) 0.98 (0.96-1.0) 0.09 Gender Male Female Ref. 0.75 (0.51-1.09) 0.13 BMI (kg/m 2 ) 18.5-24.9 ≤18.5 25-29.9 ≥30 Ref. 0.77 (0.33-1.79) 1.69 (1.12-2.55) 1.40 (0.87-2.26) 0.55 0.01 0.17 Ref. 0.82 (0.19-3.67) 2.43 (1.27-4.64) 3.06 (1.28-7.28) 0.79 <0.01 0.01 Smoking No Yes Ref. 1.06 (0.68-1.67) 0.79 Alcohol use No Yes Ref. 1.17 (0.72-1.92) 0.52 Performance status ECOG 0 ECOG 1 ECOG ≥2 Unknown Ref. 0.48 (0.31-0.74) 0.93 (0.53-1.62) 0.57 (0.33-0.97) <0.01 0.80 0.04 Albumin (mmol/L) 1.1 (1.03-1.2) <0.01 1.14 (1.06-1.23) <0.01 ACE-27 score None Mild Moderate Severe Ref. 1.04 (0.66-1.63) 0.79 (0.47-1.34) 0.52 (0.22-1.19) 0.87 0.38 0.12