151751-Najiba-Chargi

284 CHAPTER 15 SMM and muscle gain (moderate and large). In univariate Cox regression analysis, low SMM prior to initiation of CRT showed no prognostic value for decreased OS (HR 1.5; 95% CI 0.9- 2.3). No significant prognostic impact of low SMM for DFS was seen (HR 1.4; 95% CI 0.9-2.3). Low SMM after treatment showed no prognostic value for OS (HR 1.4; 95% CI 0.9-2.2) nor DFS (HR 1.3; 95% CI 0.8-2.2). Figure 2 shows the Kaplan-Meier OS and DFS curves for patients with low SMM before CRT. Figure 1. Kaplan-Meier OS and DFS curves of patients with stable SMM versus muscle changes (muscle loss and muscle gain) showed no significant differences in OS (Log-rank Chi-square 0.1, p=0.8) nor DFS (Log-rank Chi-square 0.5, p=0.5).