151751-Najiba-Chargi

303 Systemic therapy: skeletal muscle mass and oropharyngeal carcinoma Figure 2. Kaplan Meier curves and number at risk tables for overall survival (top) and disease-free survival (bottom) in OPSCC patients with and without sarcopenic obesity shows significant difference in OS (Log Rank χ 2= 4.60, p= 0.03), but not for DFS (Log Rank χ 2= 1.90, p= 0.17) As shown in table 2 and 3. univariate Cox regression analysis showed that low SMM and sar - copenic obesity were statistically significant associated with a decreased OS (HR 1.76; 95% CI 1.02-3.04, p=0.04 and HR 2.44; 95%CI 1.05-5.69, p=0.04, respectively), but not with a decreased DFS (HR 1.81; 95% CI 0.95-3.45, p=0.07 and HR 2.03; 95% CI 0.73-5.68, p=0.18, respectively). In multivariate Cox regression analysis, sarcopenic obesity remained a significant negative prognostic factor for OS (HR 3.16; 95% CI 1.31-7.63, p<0.05) and became a significant negative prognostic for DFS (HR 3.49; 95%CI 1.08-11.27, p<0.05). For OS, this result was independent of HPV-related risk group, percentage of weight loss 6months prior to diagnosis and comorbidity as assessed by the ACE-27 score and for DFS this result was independent of HPV-related risk group and BMI. 16