151751-Najiba-Chargi

325 Systemic therapy: skeletal muscle mass and functional outcomes Appendix 2. Baseline characteristics stratified by treatment modality. Number of patients (%) Total n = 108 RT n = 42 CRT cetuximab n = 17 CRT cisplatin n = 49 Gender Male 29 (69) 14 (82) 30 (61) 73 (68) Female 13 (31) 3 (18) 19 (39) 35 (32) Age at baseline Median (range) 61 (39–81) 64 (56–79) 62 (42–72) 63 (39–81) ACE-27 0 19 (45) 4 (24) 30 (61) 53 (49) 1 14 (33) 7 (41) 16 (33) 37 (34) 2 7 (17) 5 (29) 2 (4) 14 (13) 3 2 (5) 1 (6) 1 (2) 4 (4) BMI Median (range) 26 (17-44) 25 (18-33) 24 (17-32) 25 (17-44) SMM Median (range) 45 (22-64) 45 (28-54) 42 (27-54) 44 (22-64) Sarcopenia No 27 (64) 9 (53) 23 (47) 59 (55) Yes 15 (36) 8 (47) 26 (53) 49 (45) Oropharyngeal tumor site Base of tongue 16 (38) 3 (18) 16 (33) 35 (32) Tonsil 21 (50) 12 (71) 24 (49) 57 (53) Other 5 (12) 2 (12) 9 (18) 16 (15) T classification T1 19 (45) 1 (6) 7 (14) 27 (25) T2 19 (45) 6 (35) 5 (10) 30 (28) T3 3 (7) 5 (29) 21 (43) 29 (27) T4 1 (2) 5 (29) 16 (33) 22 (20) N classification N0 1 (2) 5 (29) 6 (12) 12 (11) N1 13 (31) 2 (12) 9 (18) 24 (22) N2 27 (64) 10 (59) 32 (65) 69 (64) N3 1 (2) 0 (0) 2 (4) 3 (3) AJCC stage III 14 (33) 5 (29) 9 (18) 28 (26) IV 28 (68) 12 (71) 40 (82) 80 (74) HPV status Negative 7 (18) 8 (53) 18 (38) 33 (32) Positive 33 (83) 7 (47) 30 (62) 70 (68) Unknown 2 2 1 5 Treatment modality RT 39 (93) 0 (0) 0 (0) 39 (36) RT unfit for chemo 3 (7) 0 (0) 0 (0) 3 (3) CRT (cetuximab) 0 (0) 17 (100) 0 (0) 17 (16) CRT (cisplatin) 0 (0) 0 (0) 49 (100) 49 (45) Modified diet at t 0 (FOIS < 7) No 36 (86) 16 (94) 37 (76) 89 (82) Yes 6 (14) 1 (6) 12 (24) 19 (18) Trismus at t 0 No 39 (93) 16 (94) 43 (96) 98 (94) Yes 3 (7) 1 (6) 2 (4) 6 (6) Unknown 0 0 4 4 NB: Not all percentages sum up exactly to 100% due to rounding.Abbreviations: BMI = body mass index, CRT = chemoradiotherapy (cisplatin or cetuximab based), FOIS = functional oral intake scale, HPV = human papilloma virus, other = soft palate, uvula, oropharyngeal wall, vallecula or pharyngeal arch, RT = radiotherapy, SMM = skeletal muscle mass. 17