151751-Najiba-Chargi

327 Systemic therapy: skeletal muscle mass and functional outcomes Table 2. (Continued) Total P value t 0, t 1, t 2 P value t 0 to t 1 P value t 1 to t 2 P value t 0 to t 2 t 0 n = 108 t 1 n = 99 t 2 n = 71 Modified diet (FOIS < 7) No 89 (82) 65 (66) 53 (75) .005 b .012 d ↑ .832 d .004 d ↑ Yes 19 (18) 33 (34) 18 (25) Unknown 0 1 0 Patient-rated outcome SWAL-QOL (0–100) Median (range) General burden 0 (0-88) 0 (0-100) 0 (0-50) .004 a .001 c ↑ .620 c .010 c ↑ Food selection 0 (0-88) 25 (0-100) 0 (0-50) <.001 a <.001 c ↑ .031 c ↓ .001 c ↑ Eating duration 13 (0-88) 38 (0-100) 38 (0-100) <.001 a <.001 c ↑ .431 c <.001 c ↑ Eating desire 8 (0-92) 17 (0-83) 8 (0-67) .003 a .001 c ↑ .245 c .002 c ↑ Fear 0 (0-69) 0 (0-69) 0 (0-38) .066 a .002 c ↑ .490 c .031 c ↑ Sleep 38 (0-75) 38 (0-75) 25 (0-88) .044 a .307 c .003 c ↓ .372 c Fatigue 25 (0-67) 29 (0-75) 17 (0-83) . 001 a .001 c ↑ .177 c .055 c Communication 0 (0-75) 0 (0-75) 0 (0-63) .087 a .008 c ↑ .780 c .065 c Mental health 0 (0-75) 0 (0-100) 0 (0-45) .138 a .002 c ↑ .391 c .182 c Social functioning 0 (0-70) 0 (0-60) 0 (0-30) .215 a .002 c ↑ .349 c .233 c Symptoms 7 (0-79) 16 (0-52) 13 (0-41) .003 a <.001 c ↑ .032 c .003 c ↑ Total score 5 (0-69) 14 (0-77) 9 (0-43) <.001 a <.001 c ↑ .342 c <.001 c ↑ SWAL-QOL ≥ 14 No 52 (67) 35 (52) 38 (72) .307 b .057 d .754 d .388 d Yes 26 (33) 32 (48) 15 (28) Unknown 30 32 18 Secondary outcomes Feeding tube No 106 (98) 93 (94) 71 (100) .018 b .289 d .125 d 1.000 d Yes 2 (2) 6 (6) 0 (0) Pneumonia No 98 (96) 90 (97) 67 (96) .050 b 1.000 d .250 d 1.000 d Yes 4 (4) 3 (3) 3 (4) Unknown 6 6 1 NB: Not all percentages sum up exactly to 100% due to rounding. Abbreviations: FOIS = functional oral intake scale, NGT = nasogastric tube, PRG = percutaneous radiological gastrostomy, t0 = pretreatment, t1 = six months after treatment, t2 = twelve months after treatment. 17