151751-Najiba-Chargi

331 Systemic therapy: skeletal muscle mass and functional outcomes Table 4. (Continued) Total P value t 0, t 1, t 2 P value t 0 to t 1 P value t 1 to t 2 P value t 0 to t 2 t 0 n = 108 t 1 n = 99 t 2 n = 71 Speech domain (0–56) 0 (0-42) 2 (0-32) 0 (0-31) .076 a . 005 c ↑ .045 c ↓ .580 c Psychosocial domain (0–56) 0 (0-39) 0 (0-34) 0 (0-15) .326 a .476 c .236 c .281 c Total score (0–120) 0 (0-83) 3 (0-61) 0 (0-40) .190 a .001 c ↑ .073 c .640 c SHI ≥ 6 No 65 (83) 39 (66) 36 (88) .074 b .006 d ↑ .453 d .500 d Yes 13 (17) 20 (34) 5 (12) Unknown 30 40 30 Secondary outcomes Articulation rate (syllables/s) Median (range) 2.3 (0.2-7.7) 2.6 (0.6-6.1) 2.7 (0.1-6.1) .739 a .302 c .626 c .698 c AVQI Median (range) 4.5 (3.3-5.3) 4.5 (3.4-5.5) 4.5 (3.6-5.5) .901 a .905 c .723 c .473 c NB: Not all percentages sum up exactly to 100% due to rounding. Abbreviations: AVQI = acoustic voice quality index, FOIS = functional oral intake scale, NGT = nasogastric tube, PRG = percutaneous radiological gastrostomy, SHI = speech handicap index, t0 = pretreatment, t1 = six months after treatment, t2 = twelve months after treatment Figure 4. Percentage of patients with a modified diet (FOIS < 7) (a), trismus (b) or speech problems (vowel space area < 80%) (c) at t0, t1 and t2 stratified by treatment modality. 17