151751-Najiba-Chargi

343 Systemic therapy: skeletal muscle mass and functional outcomes Appendix 10. Functional outcomes at t1 and t2 stratified by HPV status. P values shown for multivariable regression adjusted for T and N classification, treatment and modified diet at t0. t 1 t 2 HPV - n = 31 HPV + n = 64 Adjusted p value HPV - n = 18 HPV + n = 51 Adjusted p value Swallowing outcomes Modified diet (FOIS < 7) No 19 (61) 43 (68) .206 13 (72) 39 (77) .460 Yes 12 (39) 20 (32) 5 (28) 12 (24) Unknown 0 1 0 0 SWAL-QOL total score (0–100) Median (range) 21 (0-77) 8 (0-52) .492 14 (0-32) 5 (0-43) .652 SWAL-QOL ≥ 14 No 9 (38) 26 (65) .868 8 (62) 29 (76) .292 Yes 15 (63) 14 (35) 5 (39) 9 (24) Unknown 7 24 5 13 Trismus outcomes Mouth opening in mm Median (range) 42 (18-54) 45 (16-63) .627 45 (27-53) 43 (10-64) .046 Trismus No 23 (77) 43 (78) .611 15 (88) 38 (76) .086 Yes 7 (23) 12 (22) 2 (12) 12 (24) Unknown 1 9 1 1 Perceived trismus No 25 (86) 40 (80) .074 15 (94) 39 (87) .996 Yes 4 (14) 10 (20) 1 (6) 6 (13) Unknown 2 14 2 6 Speech and voice outcomes Vowel Space Area (%) Median (range) 77 (58-100) 82 (49-107) .913 77 (51-102) 76 (53-112) .528 Vowel Space Area < 80% No 13 (48) 43 (78) .645 7 (44) 16 (41) .463 Yes 14 (52) 12 (22) 9 (56) 23 (59) Unknown 4 9 2 12 SHI total score (0–120) Median (range) 4 (0-61) 3 (0-52) .896 1 (0-10) 0 (0-40) .151 SHI ≥ 6 No 12 (60) 25 (69) .995 11 (85) 24 (92) .325 Yes 8 (40) 11 (31) 2 (15) 2 (8) Unknown 11 28 5 25 NB: Not all percentages sum up exactly to 100% due to rounding. Abbreviations: FOIS = functional oral intake scale, HPV = human papillomavirus, SHI = speech handicap index, t1 = six months after treatment, t2 = twelve months after treatment. 17