151751-Najiba-Chargi

346 CHAPTER 17 Appendix 12. Functional outcomes at t1 and t2 stratified by pretreatment sarcopenia. P values shown for multivariable regression adjusted for AJCC stage and modified diet at t0. t 1 t 2 No sarcopenia n = 53 Sarcopenia n = 46 Adjusted p value No sarcopenia n = 44 Sarcopenia n = 27 Adjusted p value Swallowing outcomes Modified diet (FOIS < 7) No 41 (79) 24 (52) .013 36 (82) 17 (63) .088 Yes 11 (21) 22 (48) 8 (18) 10 (37) Unknown 1 0 0 0 SWAL-QOL total score (0–100) Median (range) 10 (0-41) 22 (0-77) .031 9 (0-32) 8 (0-43) .133 SWAL-QOL ≥ 14 No 23 (64) 12 (39) .135 26 (70) 12 (75) .783 Yes 13 (36) 19 (61) 11 (30) 4 (25) Unknown 17 15 7 11 Trismus outcomes Mouth opening in mm Median (range) 45 (27-63) 44 (16-58) .528 45 (27-64) 43 (10-52) .143 Trismus No 37 (77) 31 (78) .662 35 (81) 20 (77) .831 Yes 11 (23) 9 (23) 8 (19) 6 (23) Unknown 5 6 1 1 Perceived trismus No 37 (82) 30 (81) .958 35 (90) 21 (88) .892 Yes 8 (18) 7 (19) 4 (10) 3 (13) Unknown 8 9 5 3 Speech and voice outcomes Vowel Space Area (%) Median (range) 80 (56-107) 79 (49-100) .760 79 (51-112) 73 (53-102) .731 Vowel Space Area < 80% No 21 (49) 16 (49) .085 18 (47) 6 (32) .431 Yes 22 (51) 17 (52) 20 (53) 13 (68) Unknown 10 13 6 8 SHI total score (0–120) Median (range) 0 (0-36) 3 (0-61) .115 0 (0-23) 1 (0-40) .210 SHI ≥ 6 No 24 (73) 15 (58) .266 25 (89) 11 (85) .563 Yes 9 (27) 11 (42) 3 (11) 2 (15) Unknown 20 20 16 14 NB: Not all percentages sum up exactly to 100% due to rounding.Abbreviations: FOIS = functional oral intake scale, HPV = human papillomavirus, SHI = speech handicap index, sarcopenia = skeletal muscle mass below 43.2 cm 2 /m 2 , t1 = six months after treatment, t2 = twelve months after treatment.