151751-Najiba-Chargi

386 CHAPTER 19 FRAILTY For frailty screening, we used the G8 frailty questionnaire. This frailty screening tool consists of eight items which cover multiple geriatric domains, including nutritional status, physical capacity, mood, and polypharmacy. The G8 is specifically designed for older adult patients with cancer. Scores range from zero to seventeen, with scores ≤ fourteen representing po - tential frailty. 21 STATISTICAL ANALYSIS Data analyses were performed using IBM SPSS statistics 25. Bassline clinical characteris - tics were collected, and continuous data are represented as mean ± standard deviation (SD). Categorical data are represented as a number and percentage of total. The skeletal muscle mass was presented dichotomously as low SMI and normal SMI based on previously published specific cut-offs for SMI. Muscle function was presented dichotomously as lowmuscle function and normal muscle function based on previously published gender-specific cut-offs for hand - grip strength. Sarcopenia was presented dichotomously as sarcopenic (if patients had a low muscle function and low SMI) and non- sarcopenic (all other patients).Frailty was presented dichotomously as frail and non-frail based on previously published cut-offs for the G8 frailty screening questionnaire. Correlation between SMI, handgrip strength and the G8 frailty score were analyzed with bivar - iate Pearson’s r-correlation coefficients. Independent sample t-tests or Chi-square statistics were used for analyzing differences between the frequencies of each categorical variable with the presence or absence of frailty and presence or absence of sarcopenia. Univariate logistic regression analyses were performed, with frailty or sarcopenia as depen - dent variables and the baseline variables as independent variables. Variables were selected based on clinical relevance. Variables that were statistically significant (p< 0.05) in the uni - variate regression were included in the multivariate logistic regression with odds ratios (ORs) and 95% CIs provided. RESULTS PATIENT CHARACTERISTICS In total 150 patients with HNC diagnosed between September 2018 and January 2020 were included. Patient characteristics are presented in Table 1. The majority of the patients (67%) were male. Stage IV was the most common stage (43%). Of the included patients, 60 patients (40%) were screened as frail according to the G8 questionnaire. The majority of the patients (61%) had low SMI at diagnosis. Low handgrip strength at diagnosis was seen in a minority of the included patients (22%). Of the included patients, 21 patients (14%) were sarcopenic, as defined by low handgrip strength and low SMI. The mean time between G8 questionnaire and handgrip strength measurement (first consultation) and the CT/MRI scan was 1.8 weeks.