151751-Najiba-Chargi

389 The elderly head and neck cancer patient: sarcopenia and frailty Figure 2. Scatterplots for skeletal muscle index, handgrip strength and frailty scores. The figure illus - trates the correlation of skeletal muscle index (SMI) and G8 frailty scores (A); handgrip strength (HSG) and frailty scores (B). As seen in Table 1 , statistically significant differences were seen between patients with andwithout frailty in the presence of sarcopenia, low SMI, amount of comorbidity as evaluated by the ACE-27 score, and TNM stage. Frail patients were more likely to be sarcopenic (combination of low handgrip strength and low SMI) at diagnosis (22% versus 9%, p<0.05), to have low SMI at diagnosis (77 % versus 51%; p<0.01), to have a severe comorbidity defined by the ACE-27 score (20 % versus 7%; p<0.01), and to have a stage IV disease (54 % versus 35%; p<0.05). Statistically significant differences were found between patients with and without sarcope - nia for frailty measured by the G8, age at diagnosis, and comorbidity scores as evaluated by the ACE-27 score (Table 2). Sarcopenic patients were more likely being frail (22% versus 9%, p<0.05), to be older of age at diagnosis (mean 77 years versus 69 years; p<0.01), and to have a mild ACE-27 score (57 % versus 32%; p<0.01). Table 2. Characteristics of HNC patients with and without sarcopenia[2] Total N=150 Sarcopenic N=21 Non Sarcopenic N=129 χ 2 p-value Age (years) (M, SD) 70.3 7.26 77 8.6(SD) 69 6.4(SD) NA 0.000* Sex (n, %) Male 101 67 12 57 89 69 1.15 0.28 Female 49 33 9 43 40 31 Weight loss 6 months prior to diagnosis(n, %) Non 117 78 16 76 101 78 1.38 0.50 <10% 26 17 3 14 23 18 ≥ 10% 7 5 2 10 5 4 BMI (kg/m 2 ) (n, %) <20 53 35 10 48 43 33 4.58 0.21 19