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395 The elderly head and neck cancer patient: sarcopenia and frailty when measured by CSA at the level of C3. 35 Other limitations of our study are its retrospective and small nature. Our study also has important strengths. First, the study was performed in a large group of 150 patients. Second, because G8 and handgrip strength are routinely obtained at our institution, a consecutive series of patients were available for analysis. Third, the main observer (CM) was not aware of the diagnoses of frailty or sarcopenia in the patients. Fourth, a short period between the first consultation with G8 questionnaire and handgrip strength measurement and quantification of skeletal muscle mass was found (1.8 weeks). Fifth, all the segmentation of muscle tissue was manually performed by the first author. Because an excellent inter-ob - server agreement for skeletal musclemass measurement at the level of C3 was demonstrated, these SMI measurement findings can be used globally to select patients for potential suitable therapy. 36 In conclusion, in this study there was s an association between sarcopenia and frailty as- sessed by the G8. Therefore, assessment of skeletal musclemass may be used as an alternative screening tool for the G8 questionnaire for frailty screening, i.e., selection of patients who need a full CGA. Further research should ideally retest our findings in a larger, prospective cohort study and test for associations between sarcopenia and a full CGA. 19