151751-Najiba-Chargi

410 CHAPTER 20 patients with and without frailty, diagnosed with CGA. Frail patients were more likely to be sarcopenic (44% versus 21%, p<0.05), to be older of age (mean 83.5 years versus 79.0 years; p<0.05), to be female (69% versus 38%, p<0.05), to have a low SMI at diagnosis (90% versus 68%, p<0.05), to be frail according to the Fried criteria (49% versus 6%; p<0.00), and the GFI (77% versus 24%; p<0.00). Table 2.2. Characteristics of patients with and without frailty based on the CGA Total Frail Non frail χ 2 p-value N=73 N=39 N=34 Age (years) (M, SD) 81.73 6.24(SD) 83.49 6.47(SD) 78.96 5.03(SD) NA 0.002 Sex (n, %) Male 33 45 12 31 21 62 7.05 0.01 Female 40 55 27 69 13 38 Weight loss 6 months prior to diagnosis (n, %) Non 46 63 22 56 24 71 1.84 0.40 < 10% 20 27 12 31 8 24 ≥ 10% 7 10 5 13 2 6 BMI (kg/m 2 ) 26.80 5.70(SD) 26.98 5.66(SD) 27.02 3.69(SD) NA 0.97 Smoker (n, %) No 25 34 15 38 10 29 3.07 0.22 Former 40 55 18 46 22 65 Current 8 11 6 15 2 6 MUST score (n, %) 0 53 72 24 62 29 85 7.531 0.02 1 1 2 0 0 1 3 2 19 26 15 38 4 12 Alcohol use (n, %) No 25 34 15 38 10 29 1.50 0.68 Yes 41 56 21 54 20 59 Former 7 10 3 8 4 12 Charlson comorbidity index (n, %) Low ≤6 27 37 10 26 17 50 4.62 0.03 High >6 46 63 29 74 17 50 Localization (n, %) Oral cavity 46 63 27 69 19 56 17.39 0.24 Nasopharynx 2 3 1 3 1 3 Oropharynx 2 3 1 3 1 3 Hypopharynx 3 4 0 0 3 9