151751-Najiba-Chargi

412 CHAPTER 20 95% CI 0,78-0,98, P=0.024), frailty according CGA (OR 2.98, 95% CI 1.05-8.47, P=0.040), and frailty according Fried criteria (OR 1.92 95% CI 1.28-2.87, P=0.002) as significant variables for predicting sarcopenia. These significant variables were subjected to two different multivar - iate analyses. The first with frailty CGA and the second with frailty Fried criteria because of assumedmulticollinearity. In the first multivariate analysis only BMI (OR 0.87, 95%CI 0.77-0.98, P=0.022) remained significant. In the second age at diagnosis (OR 3.59, 95% CI 1.02-12.58, P=0.046), frailty Fried criteria (OR 1.89, 95% CI 1.22-2.93, P=0.004), and BMI (OR 0.87, 95% CI 0.76-0.99, P=0.033) remained significant. Table 3.1. Univariate and multivariate logistic regression analysis for analyzing variables associated with sarcopenia in HNC patients Sarcopenia Univariate analysis Multivariate analysis OR 95% CI P-value OR 95% CI P-value OR 95% CI P-value Age (years) ≤80 Ref. Ref. Ref. >80 3.39 1.51-9.99 0.027** 3.196 1.0-10.3 0.05 3.6 1.0-12.6 0.05** Gender Male Ref. Female 1.24 0.46-3.32 0.671 Weight loss 6 months prior to diagnosis Non Ref. <10% 0.89 0.3-2.8 0.83 ≥ 10% 1.55 0.3-7.8 0.60 BMI (kg/m 2 ) 0.87 0.8-1.0 0.02** 0.87 0.8-1.0 0.02** 0.9 0.8-1.0 0.03** Charlson comorbidity index 1.30 1.0-1.7 0.06 TNM Stage I Ref. II 0.21 0.0-1.2 0.09 III 0.24 0.0-1.5 0.13 IV 0.27 0.1-1.4 0.12 Frailty Fried criteria 1.92 1.3-2.9 0.002* 1.9 1.2-2.9 0.004* Frailty GFI No Ref. Yes 1.88 0.7-5.1 0.21 Frailty CGA No Ref. Ref. Yes 2.98 1.1-8.5 0.04** 2.54 0.8-7.8 0.1 The first with multivariate analysis is conducted with Frailty CGA and the second with Frailty Fried criteria because of assumed multicollinearity. BMI= Body Mass Index. GFI= Groningen Frailty Indicator. CGA= Comprehensive Geriatric Assessment. *. Correlation is significant at the 0.01 level (2-tailed)**. Correlation is significant at the 0.05 level (2-tailed)